Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors

Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen ar...

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Detalles Bibliográficos
Autores principales: Malchow, Sven, Leventhal, Daniel S, Savage, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782164/
https://www.ncbi.nlm.nih.gov/pubmed/24073374
http://dx.doi.org/10.4161/onci.24898
Descripción
Sumario:Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen are highly and recurrently enriched within oncogene-driven murine prostate cancers.

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