Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors

Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen ar...

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Autores principales: Malchow, Sven, Leventhal, Daniel S, Savage, Peter A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782164/
https://www.ncbi.nlm.nih.gov/pubmed/24073374
http://dx.doi.org/10.4161/onci.24898
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author Malchow, Sven
Leventhal, Daniel S
Savage, Peter A
author_facet Malchow, Sven
Leventhal, Daniel S
Savage, Peter A
author_sort Malchow, Sven
collection PubMed
description Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen are highly and recurrently enriched within oncogene-driven murine prostate cancers.
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spelling pubmed-37821642013-09-26 Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors Malchow, Sven Leventhal, Daniel S Savage, Peter A Oncoimmunology Author's View Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen are highly and recurrently enriched within oncogene-driven murine prostate cancers. Landes Bioscience 2013-07-01 2013-05-07 /pmc/articles/PMC3782164/ /pubmed/24073374 http://dx.doi.org/10.4161/onci.24898 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Malchow, Sven
Leventhal, Daniel S
Savage, Peter A
Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
title Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
title_full Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
title_fullStr Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
title_full_unstemmed Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
title_short Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
title_sort organ-specific regulatory t cells of thymic origin are expanded in murine prostate tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782164/
https://www.ncbi.nlm.nih.gov/pubmed/24073374
http://dx.doi.org/10.4161/onci.24898
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