High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?

The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated...

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Detalles Bibliográficos
Autores principales: Lugade, Amit A, Kalathil, Suresh, Miller, Austin, Iyer, Renuka, Thanavala, Yasmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782165/
https://www.ncbi.nlm.nih.gov/pubmed/24073364
http://dx.doi.org/10.4161/onci.24679
Descripción
Sumario:The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC.

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