High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?

The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated...

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Detalles Bibliográficos
Autores principales: Lugade, Amit A, Kalathil, Suresh, Miller, Austin, Iyer, Renuka, Thanavala, Yasmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782165/
https://www.ncbi.nlm.nih.gov/pubmed/24073364
http://dx.doi.org/10.4161/onci.24679
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author Lugade, Amit A
Kalathil, Suresh
Miller, Austin
Iyer, Renuka
Thanavala, Yasmin
author_facet Lugade, Amit A
Kalathil, Suresh
Miller, Austin
Iyer, Renuka
Thanavala, Yasmin
author_sort Lugade, Amit A
collection PubMed
description The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC.
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spelling pubmed-37821652013-09-26 High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored? Lugade, Amit A Kalathil, Suresh Miller, Austin Iyer, Renuka Thanavala, Yasmin Oncoimmunology Author's View The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC. Landes Bioscience 2013-07-01 2013-04-30 /pmc/articles/PMC3782165/ /pubmed/24073364 http://dx.doi.org/10.4161/onci.24679 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Lugade, Amit A
Kalathil, Suresh
Miller, Austin
Iyer, Renuka
Thanavala, Yasmin
High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
title High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
title_full High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
title_fullStr High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
title_full_unstemmed High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
title_short High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
title_sort high immunosuppressive burden in advanced hepatocellular carcinoma patients: can effector functions be restored?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782165/
https://www.ncbi.nlm.nih.gov/pubmed/24073364
http://dx.doi.org/10.4161/onci.24679
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