Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?

Accumulating evidence suggests that myeloid-derived suppressor cells (MDSCs) underpin an immunological checkpoint that is activated during inflammation or “inflammatory-like” conditions like cancer. Here, we discuss the identification of MDSCs in patients receiving allogeneic hematopoietic stem cell...

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Detalles Bibliográficos
Autores principales: Le Blanc, Katarina, Jitschin, Regina, Mougiakakos, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782166/
https://www.ncbi.nlm.nih.gov/pubmed/24073377
http://dx.doi.org/10.4161/onci.25009
Descripción
Sumario:Accumulating evidence suggests that myeloid-derived suppressor cells (MDSCs) underpin an immunological checkpoint that is activated during inflammation or “inflammatory-like” conditions like cancer. Here, we discuss the identification of MDSCs in patients receiving allogeneic hematopoietic stem cell transplantation and their potential as therapeutic targets or tools for improving the efficacy of this treatment.

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