Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?

Accumulating evidence suggests that myeloid-derived suppressor cells (MDSCs) underpin an immunological checkpoint that is activated during inflammation or “inflammatory-like” conditions like cancer. Here, we discuss the identification of MDSCs in patients receiving allogeneic hematopoietic stem cell...

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Detalles Bibliográficos
Autores principales: Le Blanc, Katarina, Jitschin, Regina, Mougiakakos, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782166/
https://www.ncbi.nlm.nih.gov/pubmed/24073377
http://dx.doi.org/10.4161/onci.25009
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author Le Blanc, Katarina
Jitschin, Regina
Mougiakakos, Dimitrios
author_facet Le Blanc, Katarina
Jitschin, Regina
Mougiakakos, Dimitrios
author_sort Le Blanc, Katarina
collection PubMed
description Accumulating evidence suggests that myeloid-derived suppressor cells (MDSCs) underpin an immunological checkpoint that is activated during inflammation or “inflammatory-like” conditions like cancer. Here, we discuss the identification of MDSCs in patients receiving allogeneic hematopoietic stem cell transplantation and their potential as therapeutic targets or tools for improving the efficacy of this treatment.
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spelling pubmed-37821662013-09-26 Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword? Le Blanc, Katarina Jitschin, Regina Mougiakakos, Dimitrios Oncoimmunology Author's View Accumulating evidence suggests that myeloid-derived suppressor cells (MDSCs) underpin an immunological checkpoint that is activated during inflammation or “inflammatory-like” conditions like cancer. Here, we discuss the identification of MDSCs in patients receiving allogeneic hematopoietic stem cell transplantation and their potential as therapeutic targets or tools for improving the efficacy of this treatment. Landes Bioscience 2013-07-01 2013-05-16 /pmc/articles/PMC3782166/ /pubmed/24073377 http://dx.doi.org/10.4161/onci.25009 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Le Blanc, Katarina
Jitschin, Regina
Mougiakakos, Dimitrios
Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
title Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
title_full Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
title_fullStr Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
title_full_unstemmed Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
title_short Myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: A double-edged sword?
title_sort myeloid-derived suppressor cells in allogeneic hematopoietic stem cell transplantation: a double-edged sword?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782166/
https://www.ncbi.nlm.nih.gov/pubmed/24073377
http://dx.doi.org/10.4161/onci.25009
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