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Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase

BACKGROUND: Alzheimer’s disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new treatments for AD. FINDINGS: A series of lycorine deriva...

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Detalles Bibliográficos
Autores principales:	Wang, Yue-Hu, Wan, Qin-Li, Gu, Cheng-Ding, Luo, Huai-Rong, Long, Chun-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782361/ https://www.ncbi.nlm.nih.gov/pubmed/22958411 http://dx.doi.org/10.1186/1752-153X-6-96

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