Localization of HPV-18 E2 at Mitochondrial Membranes Induces ROS Release and Modulates Host Cell Metabolism

Papillomavirus E2 proteins are predominantly retained in the nuclei of infected cells, but oncogenic (high-risk) HPV-18 and 16 E2 can shuttle between the host nucleus and cytoplasm. We show here that cytoplasmic HPV-18 E2 localizes to mitochondrial membranes, and independent mass spectrometry analys...

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Detalles Bibliográficos
Autores principales: Lai, Deborah, Tan, Chye Ling, Gunaratne, Jayantha, Quek, Ling Shih, Nei, Wenlong, Thierry, Françoise, Bellanger, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782431/
https://www.ncbi.nlm.nih.gov/pubmed/24086592
http://dx.doi.org/10.1371/journal.pone.0075625

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