Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD Simulations

The 16 EphA and EphB receptors represent the largest family of receptor tyrosine kinases, and their interactions with 9 ephrin-A and ephrin-B ligands initiate bidirectional signals controlling many physiological and pathological processes. Most interactions occur between receptor and ephrins of the...

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Detalles Bibliográficos
Autores principales: Huan, Xuelu, Shi, Jiahai, Lim, Liangzhong, Mitra, Sayantan, Zhu, Wanlong, Qin, Haina, Pasquale, Elena B., Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782497/
https://www.ncbi.nlm.nih.gov/pubmed/24086308
http://dx.doi.org/10.1371/journal.pone.0074040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782497/
https://www.ncbi.nlm.nih.gov/pubmed/24086308
http://dx.doi.org/10.1371/journal.pone.0074040

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