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Function-first antibody discovery: Embracing the unpredictable biology of antibodies
Therapeutic antibodies may mediate antineoplastic effects by altering the biological functions of their target, by directly stimulating the demise of cancer cells or by activating antibody-dependent immune effector mechanisms. We have recently provided in vivo proof-of-concept for a “function-first”...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782522/ https://www.ncbi.nlm.nih.gov/pubmed/24083074 http://dx.doi.org/10.4161/onci.25047 |
| _version_ | 1782285569204682752 |
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| author | Frendéus, Björn |
| author_facet | Frendéus, Björn |
| author_sort | Frendéus, Björn |
| collection | PubMed |
| description | Therapeutic antibodies may mediate antineoplastic effects by altering the biological functions of their target, by directly stimulating the demise of cancer cells or by activating antibody-dependent immune effector mechanisms. We have recently provided in vivo proof-of-concept for a “function-first” target and drug discovery platform in which antibodies against a multitude of tumor-associated antigens are screened for biological effects in a target-unbiased manner. |
| format | Online Article Text |
| id | pubmed-3782522 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-37825222013-09-30 Function-first antibody discovery: Embracing the unpredictable biology of antibodies Frendéus, Björn Oncoimmunology Author's View Therapeutic antibodies may mediate antineoplastic effects by altering the biological functions of their target, by directly stimulating the demise of cancer cells or by activating antibody-dependent immune effector mechanisms. We have recently provided in vivo proof-of-concept for a “function-first” target and drug discovery platform in which antibodies against a multitude of tumor-associated antigens are screened for biological effects in a target-unbiased manner. Landes Bioscience 2013-08-01 2013-05-20 /pmc/articles/PMC3782522/ /pubmed/24083074 http://dx.doi.org/10.4161/onci.25047 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Frendéus, Björn Function-first antibody discovery: Embracing the unpredictable biology of antibodies |
| title | Function-first antibody discovery: Embracing the unpredictable biology of antibodies |
| title_full | Function-first antibody discovery: Embracing the unpredictable biology of antibodies |
| title_fullStr | Function-first antibody discovery: Embracing the unpredictable biology of antibodies |
| title_full_unstemmed | Function-first antibody discovery: Embracing the unpredictable biology of antibodies |
| title_short | Function-first antibody discovery: Embracing the unpredictable biology of antibodies |
| title_sort | function-first antibody discovery: embracing the unpredictable biology of antibodies |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782522/ https://www.ncbi.nlm.nih.gov/pubmed/24083074 http://dx.doi.org/10.4161/onci.25047 |
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