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Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses
B7-H4 inhibits T-cell activation and is widely expressed by solid neoplasms. We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of tumor-specific T cells. Thus,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782523/ https://www.ncbi.nlm.nih.gov/pubmed/24083083 http://dx.doi.org/10.4161/onci.25913 |