VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer

Some of the anti-angiogenic agents currently used to treat solid malignancies have effects on tumor endothelial cells as well as on immune cells. We have recently demonstrated that targeting the vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 (VEGFR2) signaling pathway reduces the propo...

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Autores principales: Terme, Magali, Tartour, Eric, Taieb, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782524/
https://www.ncbi.nlm.nih.gov/pubmed/24083078
http://dx.doi.org/10.4161/onci.25156
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author Terme, Magali
Tartour, Eric
Taieb, Julien
author_facet Terme, Magali
Tartour, Eric
Taieb, Julien
author_sort Terme, Magali
collection PubMed
description Some of the anti-angiogenic agents currently used to treat solid malignancies have effects on tumor endothelial cells as well as on immune cells. We have recently demonstrated that targeting the vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 (VEGFR2) signaling pathway reduces the proportion of regulatory T cells (Treg) in a mouse model of colorectal cancer (CRC) and in metastatic CRC patients as it inhibits tumor-induced Treg proliferation.
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spelling pubmed-37825242013-09-30 VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer Terme, Magali Tartour, Eric Taieb, Julien Oncoimmunology Author's View Some of the anti-angiogenic agents currently used to treat solid malignancies have effects on tumor endothelial cells as well as on immune cells. We have recently demonstrated that targeting the vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 (VEGFR2) signaling pathway reduces the proportion of regulatory T cells (Treg) in a mouse model of colorectal cancer (CRC) and in metastatic CRC patients as it inhibits tumor-induced Treg proliferation. Landes Bioscience 2013-08-01 2013-06-10 /pmc/articles/PMC3782524/ /pubmed/24083078 http://dx.doi.org/10.4161/onci.25156 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Terme, Magali
Tartour, Eric
Taieb, Julien
VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer
title VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer
title_full VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer
title_fullStr VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer
title_full_unstemmed VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer
title_short VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory T cells in cancer
title_sort vegfa/vegfr2-targeted therapies prevent the vegfa-induced proliferation of regulatory t cells in cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782524/
https://www.ncbi.nlm.nih.gov/pubmed/24083078
http://dx.doi.org/10.4161/onci.25156
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