Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses

We have recently demonstrated that oncolytic vesicular stomatitis viruses can be efficiently and selectively delivered to neoplastic lesions by myeloid-derived suppressor cells (MDSCs). Importantly, the loading of viruses onto MDSCs inhibited their immunosuppressive properties and endowed them with...

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Autores principales: Pan, Ping-Ying, Chen, Hui-ming, Chen, Shu-Hsia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782526/
https://www.ncbi.nlm.nih.gov/pubmed/24083075
http://dx.doi.org/10.4161/onci.25083
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author Pan, Ping-Ying
Chen, Hui-ming
Chen, Shu-Hsia
author_facet Pan, Ping-Ying
Chen, Hui-ming
Chen, Shu-Hsia
author_sort Pan, Ping-Ying
collection PubMed
description We have recently demonstrated that oncolytic vesicular stomatitis viruses can be efficiently and selectively delivered to neoplastic lesions by myeloid-derived suppressor cells (MDSCs). Importantly, the loading of viruses onto MDSCs inhibited their immunosuppressive properties and endowed them with immunostimulatory and tumoricidal functions. Our study demonstrates the potential use of MDSCs as a Trojan horse for the tumor-targeted delivery of various anticancer therapeutics.
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spelling pubmed-37825262013-09-30 Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses Pan, Ping-Ying Chen, Hui-ming Chen, Shu-Hsia Oncoimmunology Author's View We have recently demonstrated that oncolytic vesicular stomatitis viruses can be efficiently and selectively delivered to neoplastic lesions by myeloid-derived suppressor cells (MDSCs). Importantly, the loading of viruses onto MDSCs inhibited their immunosuppressive properties and endowed them with immunostimulatory and tumoricidal functions. Our study demonstrates the potential use of MDSCs as a Trojan horse for the tumor-targeted delivery of various anticancer therapeutics. Landes Bioscience 2013-08-01 2013-05-28 /pmc/articles/PMC3782526/ /pubmed/24083075 http://dx.doi.org/10.4161/onci.25083 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Pan, Ping-Ying
Chen, Hui-ming
Chen, Shu-Hsia
Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses
title Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses
title_full Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses
title_fullStr Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses
title_full_unstemmed Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses
title_short Myeloid-derived suppressor cells as a Trojan horse: A cellular vehicle for the delivery of oncolytic viruses
title_sort myeloid-derived suppressor cells as a trojan horse: a cellular vehicle for the delivery of oncolytic viruses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782526/
https://www.ncbi.nlm.nih.gov/pubmed/24083075
http://dx.doi.org/10.4161/onci.25083
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