Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management

INTRODUCTION: Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration. DISCUSSION: The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis...

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Autores principales: Liau, Siong-Seng, Qureshi, M. Saeed, Praseedom, Raaj, Huguet, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782654/
https://www.ncbi.nlm.nih.gov/pubmed/23835731
http://dx.doi.org/10.1007/s11605-013-2274-6
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author Liau, Siong-Seng
Qureshi, M. Saeed
Praseedom, Raaj
Huguet, Emmanuel
author_facet Liau, Siong-Seng
Qureshi, M. Saeed
Praseedom, Raaj
Huguet, Emmanuel
author_sort Liau, Siong-Seng
collection PubMed
description INTRODUCTION: Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration. DISCUSSION: The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas. In the current article, we discuss the current evidence on the molecular biology underlying malignant transformation of hepatic adenomas and the implications for the surgical management of this disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11605-013-2274-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-37826542013-09-25 Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management Liau, Siong-Seng Qureshi, M. Saeed Praseedom, Raaj Huguet, Emmanuel J Gastrointest Surg Review Article INTRODUCTION: Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration. DISCUSSION: The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas. In the current article, we discuss the current evidence on the molecular biology underlying malignant transformation of hepatic adenomas and the implications for the surgical management of this disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11605-013-2274-6) contains supplementary material, which is available to authorized users. Springer US 2013-07-09 2013 /pmc/articles/PMC3782654/ /pubmed/23835731 http://dx.doi.org/10.1007/s11605-013-2274-6 Text en © The Society for Surgery of the Alimentary Tract 2013
spellingShingle Review Article
Liau, Siong-Seng
Qureshi, M. Saeed
Praseedom, Raaj
Huguet, Emmanuel
Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management
title Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management
title_full Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management
title_fullStr Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management
title_full_unstemmed Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management
title_short Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management
title_sort molecular pathogenesis of hepatic adenomas and its implications for surgical management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782654/
https://www.ncbi.nlm.nih.gov/pubmed/23835731
http://dx.doi.org/10.1007/s11605-013-2274-6
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