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Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the...

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Detalles Bibliográficos
Autores principales: Pepper, Andrew R., Gala-Lopez, Boris, Ziff, Oliver, Shapiro, A. M. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782812/
https://www.ncbi.nlm.nih.gov/pubmed/24106517
http://dx.doi.org/10.1155/2013/352315
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author Pepper, Andrew R.
Gala-Lopez, Boris
Ziff, Oliver
Shapiro, A. M. James
author_facet Pepper, Andrew R.
Gala-Lopez, Boris
Ziff, Oliver
Shapiro, A. M. James
author_sort Pepper, Andrew R.
collection PubMed
description Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings.
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spelling pubmed-37828122013-10-08 Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site Pepper, Andrew R. Gala-Lopez, Boris Ziff, Oliver Shapiro, A. M. James Clin Dev Immunol Review Article Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings. Hindawi Publishing Corporation 2013 2013-09-09 /pmc/articles/PMC3782812/ /pubmed/24106517 http://dx.doi.org/10.1155/2013/352315 Text en Copyright © 2013 Andrew R. Pepper et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pepper, Andrew R.
Gala-Lopez, Boris
Ziff, Oliver
Shapiro, A. M. James
Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
title Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
title_full Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
title_fullStr Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
title_full_unstemmed Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
title_short Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
title_sort revascularization of transplanted pancreatic islets and role of the transplantation site
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782812/
https://www.ncbi.nlm.nih.gov/pubmed/24106517
http://dx.doi.org/10.1155/2013/352315
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