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Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site
Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782812/ https://www.ncbi.nlm.nih.gov/pubmed/24106517 http://dx.doi.org/10.1155/2013/352315 |
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author | Pepper, Andrew R. Gala-Lopez, Boris Ziff, Oliver Shapiro, A. M. James |
author_facet | Pepper, Andrew R. Gala-Lopez, Boris Ziff, Oliver Shapiro, A. M. James |
author_sort | Pepper, Andrew R. |
collection | PubMed |
description | Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings. |
format | Online Article Text |
id | pubmed-3782812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37828122013-10-08 Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site Pepper, Andrew R. Gala-Lopez, Boris Ziff, Oliver Shapiro, A. M. James Clin Dev Immunol Review Article Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment site on graft function and survival. During the isolation process the intrinsic islet vascular networks are destroyed, leading to impaired revascularization after transplant. As a result, in some cases a significant quantity of the beta cell mass transplanted dies acutely following the infusion into the portal vein, the most clinically used site of engraftment. Subsequently, despite the majority of patients achieving insulin independence after transplant, a proportion of them recommence small, supplemental exogenous insulin over time. Herein, this review considers the process of islet revascularization after transplant, its limiting factors, and potential strategies to improve this critical step. Furthermore, we provide a characterization of alternative transplant sites, analyzing the historical evolution and their role towards advancing transplant outcomes in both the experimental and clinical settings. Hindawi Publishing Corporation 2013 2013-09-09 /pmc/articles/PMC3782812/ /pubmed/24106517 http://dx.doi.org/10.1155/2013/352315 Text en Copyright © 2013 Andrew R. Pepper et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pepper, Andrew R. Gala-Lopez, Boris Ziff, Oliver Shapiro, A. M. James Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
title | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
title_full | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
title_fullStr | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
title_full_unstemmed | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
title_short | Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site |
title_sort | revascularization of transplanted pancreatic islets and role of the transplantation site |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782812/ https://www.ncbi.nlm.nih.gov/pubmed/24106517 http://dx.doi.org/10.1155/2013/352315 |
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