Structural analysis of the yeast Dhh1–Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions

Translational repression and deadenylation of eukaryotic mRNAs result either in the sequestration of the transcripts in a nontranslatable pool or in their degradation. Removal of the 5′ cap structure is a crucial step that commits deadenylated mRNAs to 5′-to-3′ degradation. Pat1, Edc3 and the DEAD-b...

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Detalles Bibliográficos
Autores principales: Sharif, Humayun, Ozgur, Sevim, Sharma, Kundan, Basquin, Claire, Urlaub, Henning, Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783180/
https://www.ncbi.nlm.nih.gov/pubmed/23851565
http://dx.doi.org/10.1093/nar/gkt600

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