Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species

Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) an...

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Autores principales: Shigemori, Hideyuki, Kasai, Yuu, Komatsu, Kazusei, Tsuda, Masashi, Mikami, Yuzuru, Kobayashi, Jun’ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783254/
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author Shigemori, Hideyuki
Kasai, Yuu
Komatsu, Kazusei
Tsuda, Masashi
Mikami, Yuzuru
Kobayashi, Jun’ichi
author_facet Shigemori, Hideyuki
Kasai, Yuu
Komatsu, Kazusei
Tsuda, Masashi
Mikami, Yuzuru
Kobayashi, Jun’ichi
author_sort Shigemori, Hideyuki
collection PubMed
description Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa.
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spelling pubmed-37832542013-10-17 Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species Shigemori, Hideyuki Kasai, Yuu Komatsu, Kazusei Tsuda, Masashi Mikami, Yuzuru Kobayashi, Jun’ichi Mar Drugs Article Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa. Molecular Diversity Preservation International (MDPI) 2004-11-25 /pmc/articles/PMC3783254/ Text en © 2004 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Shigemori, Hideyuki
Kasai, Yuu
Komatsu, Kazusei
Tsuda, Masashi
Mikami, Yuzuru
Kobayashi, Jun’ichi
Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
title Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
title_full Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
title_fullStr Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
title_full_unstemmed Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
title_short Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
title_sort sporiolides a and b, new cytotoxic twelve-membered macrolides from a marine-derived fungus cladosporium species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783254/
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