Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells

The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parg...

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Autores principales: Tsukamoto, Sachiko, Yamashita, Yuko, Yoshida, Takushi, Ohta, Tomihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783255/
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author Tsukamoto, Sachiko
Yamashita, Yuko
Yoshida, Takushi
Ohta, Tomihisa
author_facet Tsukamoto, Sachiko
Yamashita, Yuko
Yoshida, Takushi
Ohta, Tomihisa
author_sort Tsukamoto, Sachiko
collection PubMed
description The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM, respectively.
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spelling pubmed-37832552013-10-17 Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells Tsukamoto, Sachiko Yamashita, Yuko Yoshida, Takushi Ohta, Tomihisa Mar Drugs Article The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM, respectively. Molecular Diversity Preservation International (MDPI) 2004-11-25 /pmc/articles/PMC3783255/ Text en © 2004 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Tsukamoto, Sachiko
Yamashita, Yuko
Yoshida, Takushi
Ohta, Tomihisa
Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
title Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
title_full Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
title_fullStr Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
title_full_unstemmed Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
title_short Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
title_sort parguerol and isoparguerol isolated from the sea hare, aplysia kurodai, induce neurite outgrowth in pc-12 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783255/
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