1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel

Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca(2+) channel u...

Descripción completa

Detalles Bibliográficos
Autores principales: Masuno, Makoto N., Hoepker, Alexander C., Pessah, Isaac N., Molinski, Tadeusz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783256/
_version_ 1782285644335153152
author Masuno, Makoto N.
Hoepker, Alexander C.
Pessah, Isaac N.
Molinski, Tadeusz F.
author_facet Masuno, Makoto N.
Hoepker, Alexander C.
Pessah, Isaac N.
Molinski, Tadeusz F.
author_sort Masuno, Makoto N.
collection PubMed
description Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca(2+) channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC(50) 2 μM).
format Online
Article
Text
id pubmed-3783256
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-37832562013-10-17 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel Masuno, Makoto N. Hoepker, Alexander C. Pessah, Isaac N. Molinski, Tadeusz F. Mar Drugs Article Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca(2+) channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC(50) 2 μM). Molecular Diversity Preservation International (MDPI) 2004-11-25 /pmc/articles/PMC3783256/ Text en © 2004 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Masuno, Makoto N.
Hoepker, Alexander C.
Pessah, Isaac N.
Molinski, Tadeusz F.
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
title 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
title_full 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
title_fullStr 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
title_full_unstemmed 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
title_short 1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas). Antagonists of the RyR1-FKBP12 Ca(2+) Channel
title_sort 1-o-sulfatobastadins-1 and -2 from ianthella basta (pallas). antagonists of the ryr1-fkbp12 ca(2+) channel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783256/
work_keys_str_mv AT masunomakoton 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheryr1fkbp12ca2channel
AT hoepkeralexanderc 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheryr1fkbp12ca2channel
AT pessahisaacn 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheryr1fkbp12ca2channel
AT molinskitadeuszf 1osulfatobastadins1and2fromianthellabastapallasantagonistsoftheryr1fkbp12ca2channel

Ejemplares similares