Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-Of-Function Jak2 Allele

Utilizing ENU mutagenesis, we identified a mutant mouse with elevated platelets. Genetic mapping localized the mutation to an interval on chromosome 19 that encodes the Jak2 tyrosine kinase. We identified a A3056T mutation resulting in a premature stop codon within exon 19 of Jak2 (Jak2 (K915X)), re...

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Detalles Bibliográficos
Autores principales: Anderson, Nicole M., Javadi, Mojib, Berndl, Elizabeth, Berberovic, Zorana, Bailey, Monica L., Huang, Kai, Flenniken, Ann M., Osborne, Lucy R., Adamson, S. Lee, Rossant, Janet, Carter-Su, Christin, Wang, Chen, McNagny, Kelly M., Paulson, Robert F., Minden, Mark D., Stanford, William L., Barber, Dwayne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783367/
https://www.ncbi.nlm.nih.gov/pubmed/24086539
http://dx.doi.org/10.1371/journal.pone.0075472

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