Cargando…

The Broken MLL Gene Is Frequently Located Outside the Inherent Chromosome Territory in Human Lymphoid Cells Treated with DNA Topoisomerase II Poison Etoposide

The mixed lineage leukaemia (MLL) gene is frequently rearranged in secondary leukaemias, in which it could fuse to a variety of different partners. Breakage in the MLL gene preferentially occurs within a ~8 kb region that possesses a strong DNA topoisomerase II cleavage site. It has been proposed th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glukhov, Sergey I., Rubtsov, Mikhail A., Alexeyevsky, Daniil A., Alexeevski, Andrei V., Razin, Sergey V., Iarovaia, Olga V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783379/ https://www.ncbi.nlm.nih.gov/pubmed/24086652 http://dx.doi.org/10.1371/journal.pone.0075871

Ejemplares similares

Recurrent Translocations in Topoisomerase Inhibitor-Related Leukemia Are Determined by the Features of DNA Breaks Rather Than by the Proximity of the Translocating Genes
por: Lomov, Nikolai A., et al.
Publicado: (2022)

Dynamics of double strand breaks and chromosomal translocations
por: Iarovaia, Olga V, et al.
Publicado: (2014)

Enhancer Function in the 3D Genome
por: Razin, Sergey V., et al.
Publicado: (2023)

Manipulation of Cellular Processes via Nucleolus Hijaking in the Course of Viral Infection in Mammals
por: Iarovaia, Olga V., et al.
Publicado: (2021)

Co-Regulated Genes and Gene Clusters
por: Razin, Sergey V., et al.
Publicado: (2021)

Induction of transcription within chromosomal DNA loops flanked by MAR elements causes an association of loop DNA with the nuclear matrix
por: Iarovaia, Olga V., et al.
Publicado: (2005)

Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure
por: Gavrilov, Alexey A., et al.
Publicado: (2010)

TMEM8 – a non-globin gene entrapped in the globin web
por: Philonenko, Elena S., et al.
Publicado: (2009)

Modification of Nuclear Compartments and the 3D Genome in the Course of a Viral Infection
por: Razin, S. V., et al.
Publicado: (2020)

Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub
por: Gavrilov, Alexey A., et al.
Publicado: (2013)

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ
por: Smith, Nicholas A., et al.
Publicado: (2014)

Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II
por: Le, Tung T., et al.
Publicado: (2023)

Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.
por: Ritke, M. K., et al.
Publicado: (1994)

Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide
por: Brassesco, María Sol, et al.
Publicado: (2009)

Broken by the Cut: A Journey into the Role of Topoisomerase II in DNA Fragility
por: Atkin, Naomi D., et al.
Publicado: (2019)

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide
por: Sunter, Nicola J., et al.
Publicado: (2010)

Inherent heterogeneities and nanostructural anomalies in organic glasses revealed by EPR
por: Ivanov, Mikhail Yu., et al.
Publicado: (2021)

Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase II α gene transfer is independent of topoisomerase II β
por: Zhou, Z, et al.
Publicado: (2001)

Broken drug markets in infectious diseases: Opportunities outside the private sector?
por: Alpern, Jonathan D., et al.
Publicado: (2019)

Territorial behaviour of thrush nightingales outside the breeding season
por: Brumm, Henrik, et al.
Publicado: (2023)

Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor
por: Ezoe, Sachiko
Publicado: (2012)

Supergravity with broken Lorentz invariance
por: Marakulin, Arthur, et al.
Publicado: (2016)

Gene functioning and storage within a folded genome
por: Razin, Sergey V., et al.
Publicado: (2017)

Divide and Rule: Phase Separation in Eukaryotic Genome Functioning
por: Razin, Sergey V., et al.
Publicado: (2020)

Genome-Directed Cell Nucleus Assembly
por: Razin, Sergey V., et al.
Publicado: (2022)

Transcription factories in the context of the nuclear and genome organization
por: Razin, S. V., et al.
Publicado: (2011)

Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.
por: Smith, P. J., et al.
Publicado: (1994)

UPR-Induced Resistance to Etoposide Is Downstream of PERK and Independent of Changes in Topoisomerase IIα Levels
por: Mann, Melissa J., et al.
Publicado: (2012)

Supersymmetric models with broken Lorentz invariance
por: Marakulin, Arthur, et al.
Publicado: (2017)

Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-cell lung cancer.
por: Ando, M., et al.
Publicado: (1997)

New words in human mutagenesis
por: Panchin, Alexander Y, et al.
Publicado: (2011)

Analysis of Disputed Territories in the Barents Sea
por: Demin, Sergey, et al.
Publicado: (2020)

Binding of Protein Factor CTCF within Chicken Genome Alpha-Globin Locus
por: Kotova, E. S., et al.
Publicado: (2016)

Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages
por: Ulianov, Sergey V, et al.
Publicado: (2012)

Supergravity with broken Lorentz invariance: theory and phenomenological consequences
por: Marakulin, Arthur, et al.
Publicado: (2019)

Ectopic expression of inactive forms of yeast DNA topoisomerase II confers resistance to the anti-tumour drug, etoposide.
por: Vassetzky, Y. S., et al.
Publicado: (1996)

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences
por: Infante Lara, Lorena, et al.
Publicado: (2018)

Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines
por: Matsumoto, Yoshihito, et al.
Publicado: (2001)

Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II
por: Kuriappan, Jissy A., et al.
Publicado: (2019)

The IGH locus relocalizes to a “recombination compartment” in the perinucleolar region of differentiating B-lymphocytes
por: Pichugin, Andrey, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_b9ldief6atorjo51s2us1ukrrl