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Visualization and Quantification of APP Intracellular Domain-Mediated Nuclear Signaling by Bimolecular Fluorescence Complementation

BACKGROUND: The amyloid precursor protein (APP) intracellular domain (AICD) is released from full-length APP upon sequential cleavage by either α- or β-secretase followed by γ-secretase. Together with the adaptor protein Fe65 and the histone acetyltransferase Tip60, AICD forms nuclear multiprotein c...

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Detalles Bibliográficos
Autores principales:	Riese, Florian, Grinschgl, Sonja, Gersbacher, Manuel T., Russi, Natalie, Hock, Christoph, Nitsch, Roger M., Konietzko, Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783399/ https://www.ncbi.nlm.nih.gov/pubmed/24086696 http://dx.doi.org/10.1371/journal.pone.0076094

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