The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer. The LKB1 protein is a serine-threonine kinase that phosphoryla...

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Detalles Bibliográficos
Autores principales: Nakada, Yuji, Stewart, Thomas G., Peña, Christopher G., Zhang, Song, Zhao, Ni, Bardeesy, Nabeel, Sharpless, Norman E., Wong, Kwok-Kin, Hayes, D. Neil, Castrillon, Diego H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783464/
https://www.ncbi.nlm.nih.gov/pubmed/24086281
http://dx.doi.org/10.1371/journal.pone.0073449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783464/
https://www.ncbi.nlm.nih.gov/pubmed/24086281
http://dx.doi.org/10.1371/journal.pone.0073449

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