SMG6 Cleavage Generates Metastable Decay Intermediates from Nonsense-Containing β-Globin mRNA

mRNAs targeted by endonuclease decay generally disappear without detectable decay intermediates. The exception to this is nonsense-containing human β-globin mRNA, where the destabilization of full-length mRNA is accompanied by the cytoplasmic accumulation of 5′-truncated transcripts in erythroid cel...

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Detalles Bibliográficos
Autores principales: Mascarenhas, Roshan, Dougherty, Julie A., Schoenberg, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783490/
https://www.ncbi.nlm.nih.gov/pubmed/24086375
http://dx.doi.org/10.1371/journal.pone.0074791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783490/
https://www.ncbi.nlm.nih.gov/pubmed/24086375
http://dx.doi.org/10.1371/journal.pone.0074791

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