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SMG6 Cleavage Generates Metastable Decay Intermediates from Nonsense-Containing β-Globin mRNA
mRNAs targeted by endonuclease decay generally disappear without detectable decay intermediates. The exception to this is nonsense-containing human β-globin mRNA, where the destabilization of full-length mRNA is accompanied by the cytoplasmic accumulation of 5′-truncated transcripts in erythroid cel...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783490/ https://www.ncbi.nlm.nih.gov/pubmed/24086375 http://dx.doi.org/10.1371/journal.pone.0074791 |