Smad4 loss in mouse keratinocytes leads to increased susceptibility to UV carcinogenesis with reduced Ercc1-mediated DNA repair

Smad4 loss occurs frequently in human skin squamous cell carcinoma (SCC), but it is unknown if this loss increases ultraviolet-induced (UV) carcinogenesis, a major etiological factor in skin cancer. In the present study, mice with keratinocyte-specific Smad4 deletion (K14.Smad4(−/−)) and wildtype (W...

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Detalles Bibliográficos
Autores principales: Mitra, Doyel, Fernandez, Pamela, Bian, Li, Song, Ningjing, Li, Fulun, Han, Gangwen, Wang, Xiao-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783584/
https://www.ncbi.nlm.nih.gov/pubmed/23648546
http://dx.doi.org/10.1038/jid.2013.213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783584/
https://www.ncbi.nlm.nih.gov/pubmed/23648546
http://dx.doi.org/10.1038/jid.2013.213

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