Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride

A simple, sensitive method for the determination of meta-chlorobenzoic acid in bupropion hydrochloride is described. Chromatographic separation of m-chlorobenzoic acid is achieved using a mobile phase consisting of n-hexane and ethanol (1000:50, v/v) at a flow rate of 1.0 ml/min on a Chiralpak ADH (...

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Autores principales: Sinha, Sukumar, Parashar, Vikas, Reddy, K. Swamy, Khan, Mohammad A., Haque, S. K. Manirul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783795/
https://www.ncbi.nlm.nih.gov/pubmed/24082747
http://dx.doi.org/10.4103/0976-9668.117018
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author Sinha, Sukumar
Parashar, Vikas
Reddy, K. Swamy
Khan, Mohammad A.
Haque, S. K. Manirul
author_facet Sinha, Sukumar
Parashar, Vikas
Reddy, K. Swamy
Khan, Mohammad A.
Haque, S. K. Manirul
author_sort Sinha, Sukumar
collection PubMed
description A simple, sensitive method for the determination of meta-chlorobenzoic acid in bupropion hydrochloride is described. Chromatographic separation of m-chlorobenzoic acid is achieved using a mobile phase consisting of n-hexane and ethanol (1000:50, v/v) at a flow rate of 1.0 ml/min on a Chiralpak ADH (250 × 4.6 mm). Absorbance is monitored at 235 nm. The method is linear for m-chlorobenzoic acid over concentration range of LOQ, 5.0 μg/ml to 15.0 μg/ml for m-chlorobenzoic acid with correlation coefficient greater than 0.99. This method is more selective and accurate than United States Pharmacopoeia method for the determination of m-chlorobenzoic acid in bupropion hydrochloride.
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spelling pubmed-37837952013-09-30 Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride Sinha, Sukumar Parashar, Vikas Reddy, K. Swamy Khan, Mohammad A. Haque, S. K. Manirul J Nat Sci Biol Med Original Article A simple, sensitive method for the determination of meta-chlorobenzoic acid in bupropion hydrochloride is described. Chromatographic separation of m-chlorobenzoic acid is achieved using a mobile phase consisting of n-hexane and ethanol (1000:50, v/v) at a flow rate of 1.0 ml/min on a Chiralpak ADH (250 × 4.6 mm). Absorbance is monitored at 235 nm. The method is linear for m-chlorobenzoic acid over concentration range of LOQ, 5.0 μg/ml to 15.0 μg/ml for m-chlorobenzoic acid with correlation coefficient greater than 0.99. This method is more selective and accurate than United States Pharmacopoeia method for the determination of m-chlorobenzoic acid in bupropion hydrochloride. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3783795/ /pubmed/24082747 http://dx.doi.org/10.4103/0976-9668.117018 Text en Copyright: © Journal of Natural Science, Biology and Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sinha, Sukumar
Parashar, Vikas
Reddy, K. Swamy
Khan, Mohammad A.
Haque, S. K. Manirul
Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
title Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
title_full Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
title_fullStr Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
title_full_unstemmed Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
title_short Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
title_sort liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783795/
https://www.ncbi.nlm.nih.gov/pubmed/24082747
http://dx.doi.org/10.4103/0976-9668.117018
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