Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.

The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an a...

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Autores principales: Nakao, Yoichi, Shiroiwa, Takeru, Murayama, Shuhei, Matsunaga, Shigeki, Goto, Yasuyuki, Matsumoto, Yoshitsugu, Fusetani, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783859/
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author Nakao, Yoichi
Shiroiwa, Takeru
Murayama, Shuhei
Matsunaga, Shigeki
Goto, Yasuyuki
Matsumoto, Yoshitsugu
Fusetani, Nobuhiro
author_facet Nakao, Yoichi
Shiroiwa, Takeru
Murayama, Shuhei
Matsunaga, Shigeki
Goto, Yasuyuki
Matsumoto, Yoshitsugu
Fusetani, Nobuhiro
author_sort Nakao, Yoichi
collection PubMed
description The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC(50) value of 0.2 μg/mL.
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spelling pubmed-37838592013-10-17 Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp. Nakao, Yoichi Shiroiwa, Takeru Murayama, Shuhei Matsunaga, Shigeki Goto, Yasuyuki Matsumoto, Yoshitsugu Fusetani, Nobuhiro Mar Drugs Article The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC(50) value of 0.2 μg/mL. Molecular Diversity Preservation International (MDPI) 2004-05-25 /pmc/articles/PMC3783859/ Text en © 2004 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Nakao, Yoichi
Shiroiwa, Takeru
Murayama, Shuhei
Matsunaga, Shigeki
Goto, Yasuyuki
Matsumoto, Yoshitsugu
Fusetani, Nobuhiro
Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
title Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
title_full Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
title_fullStr Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
title_full_unstemmed Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
title_short Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
title_sort identification of renieramycin a as an antileishmanial substance in a marine sponge neopetrosia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783859/
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