Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity

Two new long-chain C(33) polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC(5...

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Autores principales: Zhou, Guang-Xiong, Molinski, Tadeusz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783874/
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author Zhou, Guang-Xiong
Molinski, Tadeusz F.
author_facet Zhou, Guang-Xiong
Molinski, Tadeusz F.
author_sort Zhou, Guang-Xiong
collection PubMed
description Two new long-chain C(33) polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC(50) 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity.
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spelling pubmed-37838742013-10-17 Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity Zhou, Guang-Xiong Molinski, Tadeusz F. Mar Drugs Article Two new long-chain C(33) polyacetylenic compounds, halicynones A and B were isolated from the marine sponge Haliclona sp. along with known analogs. The known compound pellynol A possessing a 1-yn-3-ol terminus, exhibited strong antitumor activity against the human colon tumor cell line HCT-116 (IC(50) 0.026 μg/mL), however, the corresponding 1-yn-3-one, halicynone A, was inactive, which suggests an important role for the terminal 1-yn-3-ol functional group in mediating cytotoxic activity. Molecular Diversity Preservation International (MDPI) 2003-11-26 /pmc/articles/PMC3783874/ Text en © 2003 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Zhou, Guang-Xiong
Molinski, Tadeusz F.
Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
title Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
title_full Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
title_fullStr Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
title_full_unstemmed Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
title_short Long-Chain Acetylenic Ketones from the Micronesian Sponge Haliclona sp. Importance of the 1-yn-3-ol Group for Antitumor Activity
title_sort long-chain acetylenic ketones from the micronesian sponge haliclona sp. importance of the 1-yn-3-ol group for antitumor activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783874/
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AT molinskitadeuszf longchainacetylenicketonesfromthemicronesianspongehaliclonaspimportanceofthe1yn3olgroupforantitumoractivity

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