Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene

Putative precursors in pseudopterosin biosynthesis, the hydrocarbons isoelisabethatriene (10) and erogorgiaene (11), have been identified from an extract of Pseudopterogorgia elisabethae collected in the Florida Keys. Biosynthetic experiments designed to test the utilization of these compounds in ps...

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Autores principales: Kohl, Amber C., Kerr, Russell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783875/
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author Kohl, Amber C.
Kerr, Russell G.
author_facet Kohl, Amber C.
Kerr, Russell G.
author_sort Kohl, Amber C.
collection PubMed
description Putative precursors in pseudopterosin biosynthesis, the hydrocarbons isoelisabethatriene (10) and erogorgiaene (11), have been identified from an extract of Pseudopterogorgia elisabethae collected in the Florida Keys. Biosynthetic experiments designed to test the utilization of these compounds in pseudopterosin production revealed that erogorgiaene is transformed to pseudopterosins A–D. Together with our previous data, it is now apparent that early steps in pseudopterosin biosynthesis involve the cyclization of geranylgeranyl diphosphate to elisabethatriene followed by the dehydrogenation and aromatization to erogorgiaene.
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spelling pubmed-37838752013-10-17 Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene Kohl, Amber C. Kerr, Russell G. Mar Drugs Article Putative precursors in pseudopterosin biosynthesis, the hydrocarbons isoelisabethatriene (10) and erogorgiaene (11), have been identified from an extract of Pseudopterogorgia elisabethae collected in the Florida Keys. Biosynthetic experiments designed to test the utilization of these compounds in pseudopterosin production revealed that erogorgiaene is transformed to pseudopterosins A–D. Together with our previous data, it is now apparent that early steps in pseudopterosin biosynthesis involve the cyclization of geranylgeranyl diphosphate to elisabethatriene followed by the dehydrogenation and aromatization to erogorgiaene. Molecular Diversity Preservation International (MDPI) 2003-11-26 /pmc/articles/PMC3783875/ Text en © 2003 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Kohl, Amber C.
Kerr, Russell G.
Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
title Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
title_full Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
title_fullStr Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
title_full_unstemmed Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
title_short Pseudopterosin Biosynthesis: Aromatization of the Diterpene Cyclase Product, Elisabethatriene
title_sort pseudopterosin biosynthesis: aromatization of the diterpene cyclase product, elisabethatriene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783875/
work_keys_str_mv AT kohlamberc pseudopterosinbiosynthesisaromatizationofthediterpenecyclaseproductelisabethatriene
AT kerrrussellg pseudopterosinbiosynthesisaromatizationofthediterpenecyclaseproductelisabethatriene

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