An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene- 15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to...

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Autores principales: Fahmy, Hesham, Khalifa, Sherief I., Konoshima, Takao, Zjawiony, Jordan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783876/
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author Fahmy, Hesham
Khalifa, Sherief I.
Konoshima, Takao
Zjawiony, Jordan K.
author_facet Fahmy, Hesham
Khalifa, Sherief I.
Konoshima, Takao
Zjawiony, Jordan K.
author_sort Fahmy, Hesham
collection PubMed
description An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene- 15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin.
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spelling pubmed-37838762013-10-17 An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity Fahmy, Hesham Khalifa, Sherief I. Konoshima, Takao Zjawiony, Jordan K. Mar Drugs Article An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene- 15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin. Molecular Diversity Preservation International (MDPI) 2004-02-25 /pmc/articles/PMC3783876/ Text en © 2004 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Fahmy, Hesham
Khalifa, Sherief I.
Konoshima, Takao
Zjawiony, Jordan K.
An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
title An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
title_full An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
title_fullStr An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
title_full_unstemmed An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
title_short An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity
title_sort improved synthesis of 7, 8-epoxy-1,3,11-cembratriene- 15r(α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783876/
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