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The neural basis of conceptual–emotional integration and its role in major depressive disorder

The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge whe...

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Autores principales: Green, Sophie, Ralph, Matthew A. Lambon, Moll, Jorge, Zakrzewski, Jessica, Deakin, John F. William, Grafman, Jordan, Zahn, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783899/
https://www.ncbi.nlm.nih.gov/pubmed/23826933
http://dx.doi.org/10.1080/17470919.2013.810171
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author Green, Sophie
Ralph, Matthew A. Lambon
Moll, Jorge
Zakrzewski, Jessica
Deakin, John F. William
Grafman, Jordan
Zahn, Roland
author_facet Green, Sophie
Ralph, Matthew A. Lambon
Moll, Jorge
Zakrzewski, Jessica
Deakin, John F. William
Grafman, Jordan
Zahn, Roland
author_sort Green, Sophie
collection PubMed
description The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge when people with MDD appraise their social actions, contributing to their tendency to grossly overgeneralize self-blame (e.g., “I am unlikable rather than critical”). To test this hypothesis, we used a neuropsychological test measuring social conceptual differentiation and its relationship with emotional biases in a remitted MDD and a control group. During fMRI, guilt- and indignation-evoking sentences were presented. As predicted, conceptual overgeneralization was associated with increased emotional intensity when appraising social actions. Interdependence of conceptual overgeneralization and negative emotional biases was stronger in MDD (reproducible in the subgroup without medication) and was associated with overgeneralized self-blame. This high conceptual–emotional interdependence was associated with functional disconnection between the right superior anterior temporal lobe (ATL) and right dorsolateral prefrontal cortex (PFC) as well as a septal region across groups when experiencing guilt (SPM8). Strong coupling of conceptual information (ATL) with information about the context of actions and emotions (frontal-subcortical regions) is thus associated with appraisal being less dependent on conceptual overgeneralization, thereby protecting against excessive self-blame.
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spelling pubmed-37838992013-09-26 The neural basis of conceptual–emotional integration and its role in major depressive disorder Green, Sophie Ralph, Matthew A. Lambon Moll, Jorge Zakrzewski, Jessica Deakin, John F. William Grafman, Jordan Zahn, Roland Soc Neurosci Research Article The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge when people with MDD appraise their social actions, contributing to their tendency to grossly overgeneralize self-blame (e.g., “I am unlikable rather than critical”). To test this hypothesis, we used a neuropsychological test measuring social conceptual differentiation and its relationship with emotional biases in a remitted MDD and a control group. During fMRI, guilt- and indignation-evoking sentences were presented. As predicted, conceptual overgeneralization was associated with increased emotional intensity when appraising social actions. Interdependence of conceptual overgeneralization and negative emotional biases was stronger in MDD (reproducible in the subgroup without medication) and was associated with overgeneralized self-blame. This high conceptual–emotional interdependence was associated with functional disconnection between the right superior anterior temporal lobe (ATL) and right dorsolateral prefrontal cortex (PFC) as well as a septal region across groups when experiencing guilt (SPM8). Strong coupling of conceptual information (ATL) with information about the context of actions and emotions (frontal-subcortical regions) is thus associated with appraisal being less dependent on conceptual overgeneralization, thereby protecting against excessive self-blame. Taylor & Francis 2013-07-04 2013-09 /pmc/articles/PMC3783899/ /pubmed/23826933 http://dx.doi.org/10.1080/17470919.2013.810171 Text en © 2013 The Author(s). Published by Taylor & Francis. http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Taylor & Francis journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Green, Sophie
Ralph, Matthew A. Lambon
Moll, Jorge
Zakrzewski, Jessica
Deakin, John F. William
Grafman, Jordan
Zahn, Roland
The neural basis of conceptual–emotional integration and its role in major depressive disorder
title The neural basis of conceptual–emotional integration and its role in major depressive disorder
title_full The neural basis of conceptual–emotional integration and its role in major depressive disorder
title_fullStr The neural basis of conceptual–emotional integration and its role in major depressive disorder
title_full_unstemmed The neural basis of conceptual–emotional integration and its role in major depressive disorder
title_short The neural basis of conceptual–emotional integration and its role in major depressive disorder
title_sort neural basis of conceptual–emotional integration and its role in major depressive disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783899/
https://www.ncbi.nlm.nih.gov/pubmed/23826933
http://dx.doi.org/10.1080/17470919.2013.810171
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