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Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants
OBJECTIVE: The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent dev...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784106/ https://www.ncbi.nlm.nih.gov/pubmed/24327976 http://dx.doi.org/10.5468/OGS.2013.56.1.22 |
_version_ | 1782285774163542016 |
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author | Yang, Ga Young Lee, Kyung A Park, Mi Hye Park, Hye Sook Ha, Eun Hee Chun, Sun Hee Kim, Young Ju |
author_facet | Yang, Ga Young Lee, Kyung A Park, Mi Hye Park, Hye Sook Ha, Eun Hee Chun, Sun Hee Kim, Young Ju |
author_sort | Yang, Ga Young |
collection | PubMed |
description | OBJECTIVE: The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. METHODS: We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits. RESULTS: The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively. CONCLUSION: We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants. |
format | Online Article Text |
id | pubmed-3784106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology |
record_format | MEDLINE/PubMed |
spelling | pubmed-37841062013-12-10 Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants Yang, Ga Young Lee, Kyung A Park, Mi Hye Park, Hye Sook Ha, Eun Hee Chun, Sun Hee Kim, Young Ju Obstet Gynecol Sci Original Article OBJECTIVE: The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. METHODS: We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits. RESULTS: The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively. CONCLUSION: We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology 2013-01 2013-01-09 /pmc/articles/PMC3784106/ /pubmed/24327976 http://dx.doi.org/10.5468/OGS.2013.56.1.22 Text en Copyright © 2013 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yang, Ga Young Lee, Kyung A Park, Mi Hye Park, Hye Sook Ha, Eun Hee Chun, Sun Hee Kim, Young Ju Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
title | Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
title_full | Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
title_fullStr | Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
title_full_unstemmed | Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
title_short | Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
title_sort | urinary nephrin: a new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784106/ https://www.ncbi.nlm.nih.gov/pubmed/24327976 http://dx.doi.org/10.5468/OGS.2013.56.1.22 |
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