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Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age

OBJECTIVE: To evaluate the association of maternal age with occurrence of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age (AMA). METHODS: A retrospective review of the amniocentesis or chorionic villous sampling (CVS) database at Gangnam and Bundang CHA Medical Cent...

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Autores principales: Kim, Young Joo, Lee, Jee Eun, Kim, Soo Hyun, Shim, Sung Shin, Cha, Dong Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784117/
https://www.ncbi.nlm.nih.gov/pubmed/24327996
http://dx.doi.org/10.5468/ogs.2013.56.3.160
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author Kim, Young Joo
Lee, Jee Eun
Kim, Soo Hyun
Shim, Sung Shin
Cha, Dong Hyun
author_facet Kim, Young Joo
Lee, Jee Eun
Kim, Soo Hyun
Shim, Sung Shin
Cha, Dong Hyun
author_sort Kim, Young Joo
collection PubMed
description OBJECTIVE: To evaluate the association of maternal age with occurrence of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age (AMA). METHODS: A retrospective review of the amniocentesis or chorionic villous sampling (CVS) database at Gangnam and Bundang CHA Medical Centers, between January 2001 and February 2012, was conducted. This study analyzed the incidence of fetal chromosomal abnormalities according to maternal age and the correlation between maternal age and fetal chromosomal abnormalities in Korean pregnant women ≥35 years of age. In addition, we compared the prevalence of fetal chromosomal abnormalities between women of AMA only and the others as the indication for amniocentesis or CVS. RESULTS: A total of 15,381 pregnant women were selected for this study. The incidence of aneuploidies increased exponentially with maternal age (P<0.0001). In particular, the risk of trisomy 21 (standard error [SE], 0.0378; odds ratio, 1.177; P<0.001) and trisomy 18 (SE, 0.0583; odds ratio, 1.182; P=0.0040) showed significant correlation with maternal age. Comparison between women of AMA only and the others as the indication for amniocentesis or CVS showed a significantly lower rate of fetal chromosomal abnormalities only in the AMA group, compared with the others (P<0.0001). CONCLUSION: This study demonstrates that AMA is no longer used as a threshold for determination of who is offered prenatal diagnosis, but is a common risk factor for fetal chromosomal abnormalities.
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spelling pubmed-37841172013-12-10 Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age Kim, Young Joo Lee, Jee Eun Kim, Soo Hyun Shim, Sung Shin Cha, Dong Hyun Obstet Gynecol Sci Original Article OBJECTIVE: To evaluate the association of maternal age with occurrence of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age (AMA). METHODS: A retrospective review of the amniocentesis or chorionic villous sampling (CVS) database at Gangnam and Bundang CHA Medical Centers, between January 2001 and February 2012, was conducted. This study analyzed the incidence of fetal chromosomal abnormalities according to maternal age and the correlation between maternal age and fetal chromosomal abnormalities in Korean pregnant women ≥35 years of age. In addition, we compared the prevalence of fetal chromosomal abnormalities between women of AMA only and the others as the indication for amniocentesis or CVS. RESULTS: A total of 15,381 pregnant women were selected for this study. The incidence of aneuploidies increased exponentially with maternal age (P<0.0001). In particular, the risk of trisomy 21 (standard error [SE], 0.0378; odds ratio, 1.177; P<0.001) and trisomy 18 (SE, 0.0583; odds ratio, 1.182; P=0.0040) showed significant correlation with maternal age. Comparison between women of AMA only and the others as the indication for amniocentesis or CVS showed a significantly lower rate of fetal chromosomal abnormalities only in the AMA group, compared with the others (P<0.0001). CONCLUSION: This study demonstrates that AMA is no longer used as a threshold for determination of who is offered prenatal diagnosis, but is a common risk factor for fetal chromosomal abnormalities. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology 2013-05 2013-05-16 /pmc/articles/PMC3784117/ /pubmed/24327996 http://dx.doi.org/10.5468/ogs.2013.56.3.160 Text en Copyright © 2013 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Young Joo
Lee, Jee Eun
Kim, Soo Hyun
Shim, Sung Shin
Cha, Dong Hyun
Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
title Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
title_full Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
title_fullStr Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
title_full_unstemmed Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
title_short Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
title_sort maternal age-specific rates of fetal chromosomal abnormalities in korean pregnant women of advanced maternal age
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784117/
https://www.ncbi.nlm.nih.gov/pubmed/24327996
http://dx.doi.org/10.5468/ogs.2013.56.3.160
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