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Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents
Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784154/ https://www.ncbi.nlm.nih.gov/pubmed/24109492 http://dx.doi.org/10.1155/2013/614501 |
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author | Pinto, Cristiana da Purificação Rodrigues, Velize Dias Pinto, Fernanda da Purificação Pinto, Renata da Purificação Uetanabaro, Ana Paula Trovatti Pinheiro, Carla Santos Ribeiro Gadea, Suzana Ferreira Magalhães Silva, Tânia Regina dos Santos Lucchese, Angélica Maria |
author_facet | Pinto, Cristiana da Purificação Rodrigues, Velize Dias Pinto, Fernanda da Purificação Pinto, Renata da Purificação Uetanabaro, Ana Paula Trovatti Pinheiro, Carla Santos Ribeiro Gadea, Suzana Ferreira Magalhães Silva, Tânia Regina dos Santos Lucchese, Angélica Maria |
author_sort | Pinto, Cristiana da Purificação |
collection | PubMed |
description | Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine. L. origanoides leaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation of L. origanoides crude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate that L. origanoides may be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs. |
format | Online Article Text |
id | pubmed-3784154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37841542013-10-09 Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents Pinto, Cristiana da Purificação Rodrigues, Velize Dias Pinto, Fernanda da Purificação Pinto, Renata da Purificação Uetanabaro, Ana Paula Trovatti Pinheiro, Carla Santos Ribeiro Gadea, Suzana Ferreira Magalhães Silva, Tânia Regina dos Santos Lucchese, Angélica Maria Evid Based Complement Alternat Med Research Article Lippia origanoides Kunth, Lippia alnifolia Schauer, and Lippia thymoides Martius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine. L. origanoides leaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation of L. origanoides crude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate that L. origanoides may be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs. Hindawi Publishing Corporation 2013 2013-09-10 /pmc/articles/PMC3784154/ /pubmed/24109492 http://dx.doi.org/10.1155/2013/614501 Text en Copyright © 2013 Cristiana da Purificação Pinto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pinto, Cristiana da Purificação Rodrigues, Velize Dias Pinto, Fernanda da Purificação Pinto, Renata da Purificação Uetanabaro, Ana Paula Trovatti Pinheiro, Carla Santos Ribeiro Gadea, Suzana Ferreira Magalhães Silva, Tânia Regina dos Santos Lucchese, Angélica Maria Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents |
title | Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents |
title_full | Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents |
title_fullStr | Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents |
title_full_unstemmed | Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents |
title_short | Antimicrobial Activity of Lippia Species from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents |
title_sort | antimicrobial activity of lippia species from the brazilian semiarid region traditionally used as antiseptic and anti-infective agents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784154/ https://www.ncbi.nlm.nih.gov/pubmed/24109492 http://dx.doi.org/10.1155/2013/614501 |
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