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The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension
Acetaminophen is used as an analgesic and antipyretic agent. The aim of the study was evaluation of the effect of different polymers on rheological behavior of acetaminophen suspension. In order to achieve controlled flocculation, sodium chloride was added. Then structural vehicles such as carboxyme...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784229/ https://www.ncbi.nlm.nih.gov/pubmed/24109512 http://dx.doi.org/10.1155/2013/907471 |
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author | Moghimipour, Eskandar Kouchak, Maryam Salimi, Anayatollah Bahrampour, Saeed Handali, Somayeh |
author_facet | Moghimipour, Eskandar Kouchak, Maryam Salimi, Anayatollah Bahrampour, Saeed Handali, Somayeh |
author_sort | Moghimipour, Eskandar |
collection | PubMed |
description | Acetaminophen is used as an analgesic and antipyretic agent. The aim of the study was evaluation of the effect of different polymers on rheological behavior of acetaminophen suspension. In order to achieve controlled flocculation, sodium chloride was added. Then structural vehicles such as carboxymethyl cellulose (CMC), polyvinyl pyrrolidone (PVP), tragacanth, and magnesium aluminum silicate (Veegum) were evaluated individually and in combination. Physical stability parameters such as sedimentation volume (F), redispersibility (n), and growth of crystals of the suspensions were determined. Also, the rheological properties of formulations were studied. The results of this study showed that the combination of suspending agents had the most physical stability and pseudoplastic behavior with some degree of thixotropy. Viscosity of suspensions was increased by adding NaCl 0.02%. Presence of PVP is necessary for improving rheological behavior of suspensions by NaCl. This may be related to the cross-linking between the carbonyl group in the PVP segment and Na(+) ions. |
format | Online Article Text |
id | pubmed-3784229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37842292013-10-09 The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension Moghimipour, Eskandar Kouchak, Maryam Salimi, Anayatollah Bahrampour, Saeed Handali, Somayeh J Drug Deliv Research Article Acetaminophen is used as an analgesic and antipyretic agent. The aim of the study was evaluation of the effect of different polymers on rheological behavior of acetaminophen suspension. In order to achieve controlled flocculation, sodium chloride was added. Then structural vehicles such as carboxymethyl cellulose (CMC), polyvinyl pyrrolidone (PVP), tragacanth, and magnesium aluminum silicate (Veegum) were evaluated individually and in combination. Physical stability parameters such as sedimentation volume (F), redispersibility (n), and growth of crystals of the suspensions were determined. Also, the rheological properties of formulations were studied. The results of this study showed that the combination of suspending agents had the most physical stability and pseudoplastic behavior with some degree of thixotropy. Viscosity of suspensions was increased by adding NaCl 0.02%. Presence of PVP is necessary for improving rheological behavior of suspensions by NaCl. This may be related to the cross-linking between the carbonyl group in the PVP segment and Na(+) ions. Hindawi Publishing Corporation 2013 2013-09-10 /pmc/articles/PMC3784229/ /pubmed/24109512 http://dx.doi.org/10.1155/2013/907471 Text en Copyright © 2013 Eskandar Moghimipour et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Moghimipour, Eskandar Kouchak, Maryam Salimi, Anayatollah Bahrampour, Saeed Handali, Somayeh The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension |
title | The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension |
title_full | The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension |
title_fullStr | The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension |
title_full_unstemmed | The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension |
title_short | The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension |
title_sort | effect of polymer content on the non-newtonian behavior of acetaminophen suspension |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784229/ https://www.ncbi.nlm.nih.gov/pubmed/24109512 http://dx.doi.org/10.1155/2013/907471 |
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