Long-term dynamics of CA1 hippocampal place codes

Via Ca(2+)-imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, for each day the ensemble representation of this environment involved a unique subset of cells. Yet, cells...

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Detalles Bibliográficos
Autores principales: Ziv, Yaniv, Burns, Laurie D., Cocker, Eric D., Hamel, Elizabeth O., Ghosh, Kunal K., Kitch, Lacey J., El Gamal, Abbas, Schnitzer, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784308/
https://www.ncbi.nlm.nih.gov/pubmed/23396101
http://dx.doi.org/10.1038/nn.3329
Descripción
Sumario:Via Ca(2+)-imaging in freely behaving mice that repeatedly explored a familiar environment, we tracked thousands of CA1 pyramidal cells' place fields over weeks. Place coding was dynamic, for each day the ensemble representation of this environment involved a unique subset of cells. Yet, cells within the ∼15–25% overlap between any two of these subsets retained the same place fields, which sufficed to preserve an accurate spatial representation across weeks.

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