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Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine

Science is marked by the death of dogmas; the discovery that adipocytes are more than just lipid-storing cells but rather produce potent hormones is one such example that caught physiologists by surprise and reshaped our views of metabolism. While we once considered the adipocyte as a passive storag...

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Autores principales: Unger, Roger H., Scherer, Philipp E., Holland, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784375/
https://www.ncbi.nlm.nih.gov/pubmed/24072813
http://dx.doi.org/10.1091/mbc.E12-10-0774
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author Unger, Roger H.
Scherer, Philipp E.
Holland, William L.
author_facet Unger, Roger H.
Scherer, Philipp E.
Holland, William L.
author_sort Unger, Roger H.
collection PubMed
description Science is marked by the death of dogmas; the discovery that adipocytes are more than just lipid-storing cells but rather produce potent hormones is one such example that caught physiologists by surprise and reshaped our views of metabolism. While we once considered the adipocyte as a passive storage organ for efficient storage of long-term energy reserves in the form of triglyceride, we now appreciate the general idea (once a radical one) that adipocytes are sophisticated enough to have potent endocrine functions. Over the past two decades, the discoveries of these adipose-derived factors (“adipokines”) and their mechanistic actions have left us marveling at and struggling to understand the role these factors serve in physiology and the pathophysiology of obesity and diabetes. These hormones may serve an integral role in protecting nonadipose tissues from lipid-induced damage during nutrient-deprived or replete states. As such, adipocytes deliver not only potentially cytotoxic free fatty acids but, along with these lipids, antilipotoxic adipokines such as leptin, adiponectin, and fibroblast growth factor 21 that potently eliminate excessive local accumulation of these lipids or their conversion to unfavorable sphingolipid intermediates.
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spelling pubmed-37843752013-12-16 Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine Unger, Roger H. Scherer, Philipp E. Holland, William L. Mol Biol Cell Perspective Science is marked by the death of dogmas; the discovery that adipocytes are more than just lipid-storing cells but rather produce potent hormones is one such example that caught physiologists by surprise and reshaped our views of metabolism. While we once considered the adipocyte as a passive storage organ for efficient storage of long-term energy reserves in the form of triglyceride, we now appreciate the general idea (once a radical one) that adipocytes are sophisticated enough to have potent endocrine functions. Over the past two decades, the discoveries of these adipose-derived factors (“adipokines”) and their mechanistic actions have left us marveling at and struggling to understand the role these factors serve in physiology and the pathophysiology of obesity and diabetes. These hormones may serve an integral role in protecting nonadipose tissues from lipid-induced damage during nutrient-deprived or replete states. As such, adipocytes deliver not only potentially cytotoxic free fatty acids but, along with these lipids, antilipotoxic adipokines such as leptin, adiponectin, and fibroblast growth factor 21 that potently eliminate excessive local accumulation of these lipids or their conversion to unfavorable sphingolipid intermediates. The American Society for Cell Biology 2013-10-01 /pmc/articles/PMC3784375/ /pubmed/24072813 http://dx.doi.org/10.1091/mbc.E12-10-0774 Text en © 2013 Unger et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
spellingShingle Perspective
Unger, Roger H.
Scherer, Philipp E.
Holland, William L.
Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
title Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
title_full Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
title_fullStr Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
title_full_unstemmed Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
title_short Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
title_sort dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784375/
https://www.ncbi.nlm.nih.gov/pubmed/24072813
http://dx.doi.org/10.1091/mbc.E12-10-0774
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