Silencing of Doublecortin-Like (DCL) Results in Decreased Mitochondrial Activity and Delayed Neuroblastoma Tumor Growth

Doublecortin-like (DCL) is a microtubule-binding protein crucial for neuroblastoma (NB) cell proliferation. We have investigated whether the anti-proliferative effect of DCL knockdown is linked to reduced mitochondrial activity. We found a delay in tumor development after DCL knockdown in vivo in do...

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Detalles Bibliográficos
Autores principales: Verissimo, Carla S., Elands, Rachel, Cheng, Sou, Saaltink, Dirk-Jan, ter Horst, Judith P., Alme, Maria N., Pont, Chantal, van de Water, Bob, Håvik, Bjarte, Fitzsimons, Carlos P., Vreugdenhil, Erno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784435/
https://www.ncbi.nlm.nih.gov/pubmed/24086625
http://dx.doi.org/10.1371/journal.pone.0075752

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