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Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
In colorectal cancer cells, APC, a tumor suppressor protein, is commonly expressed in truncated form. Truncation of APC is believed to disrupt degradation of β—catenin[Image: see text], which is regulated by a multiprotein complex called the destruction complex. The destruction complex comprises APC...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784502/ https://www.ncbi.nlm.nih.gov/pubmed/24086117 http://dx.doi.org/10.1371/journal.pcbi.1003217 |