Cargando…

Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis

Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location....

Descripción completa

Detalles Bibliográficos
Autores principales: Borgohain, Mondita, Gogoi, Gayatri, Das, Dipak, Biswas, Manjusha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784880/
https://www.ncbi.nlm.nih.gov/pubmed/24083178
http://dx.doi.org/10.4103/2230-8210.117217
_version_ 1782477605517131776
author Borgohain, Mondita
Gogoi, Gayatri
Das, Dipak
Biswas, Manjusha
author_facet Borgohain, Mondita
Gogoi, Gayatri
Das, Dipak
Biswas, Manjusha
author_sort Borgohain, Mondita
collection PubMed
description Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking any one of the more common primary pancreatic lesions. Pancreatic paraganglioma is an extremely rare tumor. It grows slowly, so radical resection is recommended to achieve curability with good prognosis. These neoplasms present considerable diagnostic difficulty not only for the clinician and radiologist but also for the pathologist. Here, we report a case of a 55-year-old woman who presented with a left-sided abdominal swelling for 3 months duration, initially having clinical suspicion of an ovarian tumor. The radiological imaging revealed a lesion in the tail of pancreas with a differential diagnosis of pancreatic carcinoma and metastatic tumor. Only after exploratory laparotomy, the diagnosis was made as a rare case of pancreatic paraganglioma on the basis of histological examination and immunohistochemistry.
format Online
Article
Text
id pubmed-3784880
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-37848802013-09-30 Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis Borgohain, Mondita Gogoi, Gayatri Das, Dipak Biswas, Manjusha Indian J Endocrinol Metab Case Report with Review of Literature Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking any one of the more common primary pancreatic lesions. Pancreatic paraganglioma is an extremely rare tumor. It grows slowly, so radical resection is recommended to achieve curability with good prognosis. These neoplasms present considerable diagnostic difficulty not only for the clinician and radiologist but also for the pathologist. Here, we report a case of a 55-year-old woman who presented with a left-sided abdominal swelling for 3 months duration, initially having clinical suspicion of an ovarian tumor. The radiological imaging revealed a lesion in the tail of pancreas with a differential diagnosis of pancreatic carcinoma and metastatic tumor. Only after exploratory laparotomy, the diagnosis was made as a rare case of pancreatic paraganglioma on the basis of histological examination and immunohistochemistry. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3784880/ /pubmed/24083178 http://dx.doi.org/10.4103/2230-8210.117217 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report with Review of Literature
Borgohain, Mondita
Gogoi, Gayatri
Das, Dipak
Biswas, Manjusha
Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
title Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
title_full Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
title_fullStr Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
title_full_unstemmed Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
title_short Pancreatic paraganglioma: An extremely rare entity and crucial role of immunohistochemistry for diagnosis
title_sort pancreatic paraganglioma: an extremely rare entity and crucial role of immunohistochemistry for diagnosis
topic Case Report with Review of Literature
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784880/
https://www.ncbi.nlm.nih.gov/pubmed/24083178
http://dx.doi.org/10.4103/2230-8210.117217
work_keys_str_mv AT borgohainmondita pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis
AT gogoigayatri pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis
AT dasdipak pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis
AT biswasmanjusha pancreaticparagangliomaanextremelyrareentityandcrucialroleofimmunohistochemistryfordiagnosis