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Using Xpert MTB/RIF
Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Sin...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham open
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785149/ https://www.ncbi.nlm.nih.gov/pubmed/24089608 http://dx.doi.org/10.2174/1573398X113099990015 |
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author | Nicol, Mark P. Whitelaw, Andrew Wendy, Stevens |
author_facet | Nicol, Mark P. Whitelaw, Andrew Wendy, Stevens |
author_sort | Nicol, Mark P. |
collection | PubMed |
description | Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Since sample processing and detection are largely automated, Xpert MTB/RIF is potentially suitable for implementation in resource-limited settings. There are, however, a number of practical constraints to the use of Xpert at the point-of-care. Xpert remains a relatively costly test, and clear demonstration of cost-effectiveness will be needed to support efforts to scale up testing in high burden countries. |
format | Online Article Text |
id | pubmed-3785149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham open |
record_format | MEDLINE/PubMed |
spelling | pubmed-37851492013-09-30 Using Xpert MTB/RIF Nicol, Mark P. Whitelaw, Andrew Wendy, Stevens Curr Respir Med Rev Article Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Since sample processing and detection are largely automated, Xpert MTB/RIF is potentially suitable for implementation in resource-limited settings. There are, however, a number of practical constraints to the use of Xpert at the point-of-care. Xpert remains a relatively costly test, and clear demonstration of cost-effectiveness will be needed to support efforts to scale up testing in high burden countries. Bentham open 2013-06 2013-06 /pmc/articles/PMC3785149/ /pubmed/24089608 http://dx.doi.org/10.2174/1573398X113099990015 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Nicol, Mark P. Whitelaw, Andrew Wendy, Stevens Using Xpert MTB/RIF |
title | Using Xpert MTB/RIF |
title_full | Using Xpert MTB/RIF |
title_fullStr | Using Xpert MTB/RIF |
title_full_unstemmed | Using Xpert MTB/RIF |
title_short | Using Xpert MTB/RIF |
title_sort | using xpert mtb/rif |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785149/ https://www.ncbi.nlm.nih.gov/pubmed/24089608 http://dx.doi.org/10.2174/1573398X113099990015 |
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