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Using Xpert MTB/RIF

Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Sin...

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Detalles Bibliográficos
Autores principales: Nicol, Mark P., Whitelaw, Andrew, Wendy, Stevens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham open 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785149/
https://www.ncbi.nlm.nih.gov/pubmed/24089608
http://dx.doi.org/10.2174/1573398X113099990015
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author Nicol, Mark P.
Whitelaw, Andrew
Wendy, Stevens
author_facet Nicol, Mark P.
Whitelaw, Andrew
Wendy, Stevens
author_sort Nicol, Mark P.
collection PubMed
description Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Since sample processing and detection are largely automated, Xpert MTB/RIF is potentially suitable for implementation in resource-limited settings. There are, however, a number of practical constraints to the use of Xpert at the point-of-care. Xpert remains a relatively costly test, and clear demonstration of cost-effectiveness will be needed to support efforts to scale up testing in high burden countries.
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spelling pubmed-37851492013-09-30 Using Xpert MTB/RIF Nicol, Mark P. Whitelaw, Andrew Wendy, Stevens Curr Respir Med Rev Article Xpert MTB/RIF is an automated real-time polymerase chain reaction test for simultaneous detection of tuberculosis and rifampicin resistance. Xpert MTB/RIF has demonstrated excellent accuracy in clinical evaluation studies, but has reduced sensitivity for detection of smear-negative tuberculosis. Since sample processing and detection are largely automated, Xpert MTB/RIF is potentially suitable for implementation in resource-limited settings. There are, however, a number of practical constraints to the use of Xpert at the point-of-care. Xpert remains a relatively costly test, and clear demonstration of cost-effectiveness will be needed to support efforts to scale up testing in high burden countries. Bentham open 2013-06 2013-06 /pmc/articles/PMC3785149/ /pubmed/24089608 http://dx.doi.org/10.2174/1573398X113099990015 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Nicol, Mark P.
Whitelaw, Andrew
Wendy, Stevens
Using Xpert MTB/RIF
title Using Xpert MTB/RIF
title_full Using Xpert MTB/RIF
title_fullStr Using Xpert MTB/RIF
title_full_unstemmed Using Xpert MTB/RIF
title_short Using Xpert MTB/RIF
title_sort using xpert mtb/rif
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785149/
https://www.ncbi.nlm.nih.gov/pubmed/24089608
http://dx.doi.org/10.2174/1573398X113099990015
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