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Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista

BACKGROUND: Arthropod venoms have attracted interest because they represent a source of neuroactive compounds that can be useful tools in neuroscience and pharmacological investigations. OBJECTIVE: The purpose of the present work was to evaluate the anticonvulsant, anxiolytic, and behavioral effects...

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Autores principales: do Couto, Lucianna Lopes, dos Anjos, Lilian Carneiro, Araujo, Maíra de Azevedo Feitosa, Mourão, Cecília Alves, Schwartz, Carlos Aberto, Ferreira, Luzitano Brandão, Mortari, Márcia Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785167/
https://www.ncbi.nlm.nih.gov/pubmed/24082633
http://dx.doi.org/10.4103/0973-1296.103657
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author do Couto, Lucianna Lopes
dos Anjos, Lilian Carneiro
Araujo, Maíra de Azevedo Feitosa
Mourão, Cecília Alves
Schwartz, Carlos Aberto
Ferreira, Luzitano Brandão
Mortari, Márcia Renata
author_facet do Couto, Lucianna Lopes
dos Anjos, Lilian Carneiro
Araujo, Maíra de Azevedo Feitosa
Mourão, Cecília Alves
Schwartz, Carlos Aberto
Ferreira, Luzitano Brandão
Mortari, Márcia Renata
author_sort do Couto, Lucianna Lopes
collection PubMed
description BACKGROUND: Arthropod venoms have attracted interest because they represent a source of neuroactive compounds that can be useful tools in neuroscience and pharmacological investigations. OBJECTIVE: The purpose of the present work was to evaluate the anticonvulsant, anxiolytic, and behavioral effects of the peptide fraction separated from venom of the social wasp. MATERIALS AND METHODS: The low- molecular-weight compounds of the venom were separated by ultrafiltration and the bioassays were performed to test anticonvulsant and anxiolytic effects, as well as alterations in the spontaneous behavior of the animals. RESULTS: Intracerebroventricular injections of the compounds induced dose-dependent anticonvulsant effects and a potent anxiolytic activity. Regarding behavioral effects, no significant differences were observed in relation to the saline control group. CONCLUSION: The low-molecular-weight compounds of the venom of Polybia paulista include neuroactive peptides that can be used as pharmacological resources for anticonvulsant and anxiolytic drug research.
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spelling pubmed-37851672013-09-30 Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista do Couto, Lucianna Lopes dos Anjos, Lilian Carneiro Araujo, Maíra de Azevedo Feitosa Mourão, Cecília Alves Schwartz, Carlos Aberto Ferreira, Luzitano Brandão Mortari, Márcia Renata Pharmacogn Mag Original Article BACKGROUND: Arthropod venoms have attracted interest because they represent a source of neuroactive compounds that can be useful tools in neuroscience and pharmacological investigations. OBJECTIVE: The purpose of the present work was to evaluate the anticonvulsant, anxiolytic, and behavioral effects of the peptide fraction separated from venom of the social wasp. MATERIALS AND METHODS: The low- molecular-weight compounds of the venom were separated by ultrafiltration and the bioassays were performed to test anticonvulsant and anxiolytic effects, as well as alterations in the spontaneous behavior of the animals. RESULTS: Intracerebroventricular injections of the compounds induced dose-dependent anticonvulsant effects and a potent anxiolytic activity. Regarding behavioral effects, no significant differences were observed in relation to the saline control group. CONCLUSION: The low-molecular-weight compounds of the venom of Polybia paulista include neuroactive peptides that can be used as pharmacological resources for anticonvulsant and anxiolytic drug research. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3785167/ /pubmed/24082633 http://dx.doi.org/10.4103/0973-1296.103657 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
do Couto, Lucianna Lopes
dos Anjos, Lilian Carneiro
Araujo, Maíra de Azevedo Feitosa
Mourão, Cecília Alves
Schwartz, Carlos Aberto
Ferreira, Luzitano Brandão
Mortari, Márcia Renata
Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista
title Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista
title_full Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista
title_fullStr Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista
title_full_unstemmed Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista
title_short Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista
title_sort anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp polybia paulista
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785167/
https://www.ncbi.nlm.nih.gov/pubmed/24082633
http://dx.doi.org/10.4103/0973-1296.103657
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