Effect and evaluation of antihyperlipidemic activity guided isolated fraction from total methanol extract of Salvadora oleoides (Decne.) in Triton WR-1339 Induced hyperlipidemic rats

BACKGROUND: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieties of synthetic drugs are used in the treatment, still the searches are on for better medicaments especially from the plant kingdom. Many medicinal plants have been studied in this context but most of them are seasonal or have restricted availability. One such weed, available throughout the year is Salvadora oleoides (decne.). MATERIALS AND METHODS: Column chromatographic fractionation of the butanol fraction of leaves of Salvadora oleoides (decne.) yielded four fractions (fraction A-D). All sub-fractions were tested for their anti-hyperlipidemic activity. Fractions were administered at a dose of 65 mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. RESULTS: Sub-fraction D showed maximum significant reduction (P<0.05) among four sub-fractions in comparison with standard drug fenofibrate. CONCLUSION: Further studies on the isolated fractions and constituents are needed to isolate compound responsible for activity and elucidate the mechanism by which Salvadora oleoides (decne.) exerts protective effects against hyperlipidemia.