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Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress
BACKGROUND: The beneficial effects of antioxidants in plants are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary antioxidants are beneficial in whole animals’ life span or not. MATERIA...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785172/ https://www.ncbi.nlm.nih.gov/pubmed/24082638 http://dx.doi.org/10.4103/0973-1296.103666 |
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author | Kılıçgün, Hasan Göksen, Gülden |
author_facet | Kılıçgün, Hasan Göksen, Gülden |
author_sort | Kılıçgün, Hasan |
collection | PubMed |
description | BACKGROUND: The beneficial effects of antioxidants in plants are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary antioxidants are beneficial in whole animals’ life span or not. MATERIALS AND METHODS: To address this question, under heat stress (35°C), Hypericum perforatum was extracted with petroleum ether and the nematodes Caenorhabditis elegans exposed to three different extract concentrations (1mg/mL, 0.1mg/mL, 0.01mg/mL) of H. perforatum. RESULTS: We report that Hypericum perforatum extracts did not increase life span and slow aging related increase in C. elegans. Moreover, one fraction (1mg/mL) increased declines of C. elegans life span and thermotolerance. CONCLUSION: Given this mounting evidence for life span role of H. perforatum in the presence of heat stress in vivo, the question whether H. perforatum acts as a prooxidant or an antioxidant in vivo under heat stress arises. |
format | Online Article Text |
id | pubmed-3785172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37851722013-09-30 Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress Kılıçgün, Hasan Göksen, Gülden Pharmacogn Mag Original Article BACKGROUND: The beneficial effects of antioxidants in plants are mainly extrapolated from in vitro studies or short-term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary antioxidants are beneficial in whole animals’ life span or not. MATERIALS AND METHODS: To address this question, under heat stress (35°C), Hypericum perforatum was extracted with petroleum ether and the nematodes Caenorhabditis elegans exposed to three different extract concentrations (1mg/mL, 0.1mg/mL, 0.01mg/mL) of H. perforatum. RESULTS: We report that Hypericum perforatum extracts did not increase life span and slow aging related increase in C. elegans. Moreover, one fraction (1mg/mL) increased declines of C. elegans life span and thermotolerance. CONCLUSION: Given this mounting evidence for life span role of H. perforatum in the presence of heat stress in vivo, the question whether H. perforatum acts as a prooxidant or an antioxidant in vivo under heat stress arises. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3785172/ /pubmed/24082638 http://dx.doi.org/10.4103/0973-1296.103666 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kılıçgün, Hasan Göksen, Gülden Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress |
title | Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress |
title_full | Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress |
title_fullStr | Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress |
title_full_unstemmed | Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress |
title_short | Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress |
title_sort | life span effects of hypericum perforatum extracts on caenorhabditis elegans under heat stress |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785172/ https://www.ncbi.nlm.nih.gov/pubmed/24082638 http://dx.doi.org/10.4103/0973-1296.103666 |
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