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Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden
BACKGROUND: It is important to identify patients who are at risk for infections with extended-spectrum β-lactamase (ESBL)-producing bacteria in order to reduce mortality, to avoid spread of resistant bacteria in hospitals, and to minimize the number of patients receiving unnecessary treatment with b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785393/ https://www.ncbi.nlm.nih.gov/pubmed/24082789 http://dx.doi.org/10.2147/IDR.S46290 |
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author | Tham, Johan Odenholt, Inga Walder, Mats Andersson, Lina Melander, Eva |
author_facet | Tham, Johan Odenholt, Inga Walder, Mats Andersson, Lina Melander, Eva |
author_sort | Tham, Johan |
collection | PubMed |
description | BACKGROUND: It is important to identify patients who are at risk for infections with extended-spectrum β-lactamase (ESBL)-producing bacteria in order to reduce mortality, to avoid spread of resistant bacteria in hospitals, and to minimize the number of patients receiving unnecessary treatment with broad-spectrum antibiotics. A case-control survey among Swedish patients was performed at Skåne University Hospital to identify risk factors for developing an infection with ESBL-producing Escherichia coli in a low endemic country. METHODS: We used a computerized database to identify patients with growth of ESBL-producing E. coli (n = 109) in urine or blood cultures and an equal number of controls matched for age and gender with non ESBL-producing E. coli in urine and blood diagnosed between January and October 2008. We used unadjusted P-values. RESULTS: Patients with ESBL-producing E. coli had a significantly (P < 0.05) higher likelihood of having traveled to Asia including Turkey and the Middle East including Egypt (14/58) than the non-ESBL-positive group (4/53). Hospital stay during the previous year (P < 0.04), especially for more than one month, was another significant (P = 0.01) risk factor for infection with ESBL-producing E. coli (8/58). A stay in the surgical department was a further risk factor (P < 0.01). CONCLUSION: In this study, we identified 22 of 58 (38%) patients with ESBL-producing E. coli by considered significant risk factors before starting antibiotics. |
format | Online Article Text |
id | pubmed-3785393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37853932013-09-30 Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden Tham, Johan Odenholt, Inga Walder, Mats Andersson, Lina Melander, Eva Infect Drug Resist Original Research BACKGROUND: It is important to identify patients who are at risk for infections with extended-spectrum β-lactamase (ESBL)-producing bacteria in order to reduce mortality, to avoid spread of resistant bacteria in hospitals, and to minimize the number of patients receiving unnecessary treatment with broad-spectrum antibiotics. A case-control survey among Swedish patients was performed at Skåne University Hospital to identify risk factors for developing an infection with ESBL-producing Escherichia coli in a low endemic country. METHODS: We used a computerized database to identify patients with growth of ESBL-producing E. coli (n = 109) in urine or blood cultures and an equal number of controls matched for age and gender with non ESBL-producing E. coli in urine and blood diagnosed between January and October 2008. We used unadjusted P-values. RESULTS: Patients with ESBL-producing E. coli had a significantly (P < 0.05) higher likelihood of having traveled to Asia including Turkey and the Middle East including Egypt (14/58) than the non-ESBL-positive group (4/53). Hospital stay during the previous year (P < 0.04), especially for more than one month, was another significant (P = 0.01) risk factor for infection with ESBL-producing E. coli (8/58). A stay in the surgical department was a further risk factor (P < 0.01). CONCLUSION: In this study, we identified 22 of 58 (38%) patients with ESBL-producing E. coli by considered significant risk factors before starting antibiotics. Dove Medical Press 2013-09-19 /pmc/articles/PMC3785393/ /pubmed/24082789 http://dx.doi.org/10.2147/IDR.S46290 Text en © 2013 Tham et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Tham, Johan Odenholt, Inga Walder, Mats Andersson, Lina Melander, Eva Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden |
title | Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden |
title_full | Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden |
title_fullStr | Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden |
title_full_unstemmed | Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden |
title_short | Risk factors for infections with extended-spectrum beta-lactamase-producing Escherichia coli in a county of Southern Sweden |
title_sort | risk factors for infections with extended-spectrum beta-lactamase-producing escherichia coli in a county of southern sweden |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785393/ https://www.ncbi.nlm.nih.gov/pubmed/24082789 http://dx.doi.org/10.2147/IDR.S46290 |
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