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Effect of Selectively Introducing Arginine and D-Amino Acids on the Antimicrobial Activity and Salt Sensitivity in Analogs of Human Beta-Defensins

We have examined the antimicrobial activity of C-terminal analogs of human β-defensins HBD-1and-3 wherein lysines have been selectively replaced by L- and D-arginines and L-isoleucine substituted with its D-enantiomer. The analogs exhibited antibacterial and antifungal activities. Physiological conc...

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Detalles Bibliográficos
Autores principales:	Olli, Sudar, Rangaraj, Nandini, Nagaraj, Ramakrishnan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785448/ https://www.ncbi.nlm.nih.gov/pubmed/24086767 http://dx.doi.org/10.1371/journal.pone.0077031

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