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Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones

BACKGROUND: The impact of global warming and associated climate changes have built up pressure to focus on the option of green chemistry over traditional one for long term sustainability of the environment. Considering the fact, for the first time, efficient HLE catalysed expeditious one-pot synthes...

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Autores principales: Singh, Udaya Pratap, Bhat, Hans Raj, Kumawat, Mukesh Kumar, Singh, Ramendra K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786069/
https://www.ncbi.nlm.nih.gov/pubmed/24083113
http://dx.doi.org/10.1186/2193-1801-2-466
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author Singh, Udaya Pratap
Bhat, Hans Raj
Kumawat, Mukesh Kumar
Singh, Ramendra K
author_facet Singh, Udaya Pratap
Bhat, Hans Raj
Kumawat, Mukesh Kumar
Singh, Ramendra K
author_sort Singh, Udaya Pratap
collection PubMed
description BACKGROUND: The impact of global warming and associated climate changes have built up pressure to focus on the option of green chemistry over traditional one for long term sustainability of the environment. Considering the fact, for the first time, efficient HLE catalysed expeditious one-pot synthesis of highly functionalised 4-thiazolidinones has been developed. RESULTS: These hybrid molecules were synthesized in good to excellent yields. The ease of work-up of the reactions less time required and mild conditions are notable features of this protocol. It was inferred that halogen containing derivatives were well suited to this condensation-cyclization reaction with varying rates to afford 4-thiazolidine derivatives. In general, the substitution on the aldehyde part was shown as a main determinant for reaction time and the product yield. CONCLUSION: For the first time home laundry effluent (HLE) owing to the surfactant like property has been successfully utilised as catalyst for the synthesis of a series of novel 4-thiazolidinone derivatives through one pot, three component condensation-cyclization reaction. The uniqueness of the present protocol lies in the operational simplicity, ability to reduce the demand for organic solvents, reduce the energy and carbon footprint, and meet a wide range of economic needs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-2-466) contains supplementary material, which is available to authorized users.
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spelling pubmed-37860692013-09-30 Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones Singh, Udaya Pratap Bhat, Hans Raj Kumawat, Mukesh Kumar Singh, Ramendra K Springerplus Research BACKGROUND: The impact of global warming and associated climate changes have built up pressure to focus on the option of green chemistry over traditional one for long term sustainability of the environment. Considering the fact, for the first time, efficient HLE catalysed expeditious one-pot synthesis of highly functionalised 4-thiazolidinones has been developed. RESULTS: These hybrid molecules were synthesized in good to excellent yields. The ease of work-up of the reactions less time required and mild conditions are notable features of this protocol. It was inferred that halogen containing derivatives were well suited to this condensation-cyclization reaction with varying rates to afford 4-thiazolidine derivatives. In general, the substitution on the aldehyde part was shown as a main determinant for reaction time and the product yield. CONCLUSION: For the first time home laundry effluent (HLE) owing to the surfactant like property has been successfully utilised as catalyst for the synthesis of a series of novel 4-thiazolidinone derivatives through one pot, three component condensation-cyclization reaction. The uniqueness of the present protocol lies in the operational simplicity, ability to reduce the demand for organic solvents, reduce the energy and carbon footprint, and meet a wide range of economic needs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2193-1801-2-466) contains supplementary material, which is available to authorized users. Springer International Publishing 2013-09-16 /pmc/articles/PMC3786069/ /pubmed/24083113 http://dx.doi.org/10.1186/2193-1801-2-466 Text en © Singh et al.; licensee Springer. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Singh, Udaya Pratap
Bhat, Hans Raj
Kumawat, Mukesh Kumar
Singh, Ramendra K
Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
title Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
title_full Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
title_fullStr Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
title_full_unstemmed Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
title_short Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
title_sort utilisation of home laundry effluent (hle) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786069/
https://www.ncbi.nlm.nih.gov/pubmed/24083113
http://dx.doi.org/10.1186/2193-1801-2-466
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