Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case–control epidemiological observations

We investigated the role of interleukin (IL)-4 receptor (IL-4R) signalling during mouse carcinogen-induced colorectal carcinogenesis and in a case–control genetic epidemiological study of IL-4Rα single nucleotide polymorphisms (SNPs). Azoxymethane-induced aberrant crypt focus (ACF; 6 weeks) and tumo...

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Detalles Bibliográficos
Autores principales: Ingram, Nicola, Northwood, Emma L., Perry, Sarah L., Marston, Gemma, Snowden, Helen, Taylor, John C., Scott, Nigel, Bishop, D. Timothy, Coletta, P. Louise, Hull, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Manuscript
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786383/
https://www.ncbi.nlm.nih.gov/pubmed/23784081
http://dx.doi.org/10.1093/carcin/bgt222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786383/
https://www.ncbi.nlm.nih.gov/pubmed/23784081
http://dx.doi.org/10.1093/carcin/bgt222

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