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Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy?
This study studied the coorelation between radiological response to induction chemotherapy and acheivement of pCR or near pCR. It was a retrospective analysis in which all patients who received NACT from 2008 till april 2012 were subjected to inclusion criteria. Coorelation analysis was performed be...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786467/ https://www.ncbi.nlm.nih.gov/pubmed/24109521 http://dx.doi.org/10.1155/2013/259154 |
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author | Patil, V. Noronha, V. Joshi, A. Muddu Krishna, Vamshi Juvekar, S. Pantvaidya, Gauri Chaturvedi, Pankaj Chaukar, D. Arya, Supreeta Patil, Aswari Bhosale, B. Dongre, A. Dcruz, A. K. Prabhash, K. |
author_facet | Patil, V. Noronha, V. Joshi, A. Muddu Krishna, Vamshi Juvekar, S. Pantvaidya, Gauri Chaturvedi, Pankaj Chaukar, D. Arya, Supreeta Patil, Aswari Bhosale, B. Dongre, A. Dcruz, A. K. Prabhash, K. |
author_sort | Patil, V. |
collection | PubMed |
description | This study studied the coorelation between radiological response to induction chemotherapy and acheivement of pCR or near pCR. It was a retrospective analysis in which all patients who received NACT from 2008 till april 2012 were subjected to inclusion criteria. Coorelation analysis was performed between CR + PR and acheivement of pCR or near pCR. Twenty four patients were identified.The primary site of tumor was oral cavity in 19 patients (79.2%), maxilla in 2 patients (4.2%), laryngopharynx in 2 patients (4.2%) and oropharynx in 1 patient (4.2%). The clinical stage was stage IVA in 16 patients ( 66.7%) and IVB in 8 patients (33.3%). The overall response rates ie a combination of CR and PR was seen in 11patients (45.8%). The pCR was seen in 15 patients (62.5%) and rest had near pCR. There was no linear coorelation between radiological size decrement and tumor response. On coorelation analysis the spearman correlation coefficent was −0.039 (P = 0.857). This suggest that presently used radiological response criterias for response assesment in head and neck cancers severly limit our ability to identify patients who would have pCR or near pCR. |
format | Online Article Text |
id | pubmed-3786467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37864672013-10-09 Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? Patil, V. Noronha, V. Joshi, A. Muddu Krishna, Vamshi Juvekar, S. Pantvaidya, Gauri Chaturvedi, Pankaj Chaukar, D. Arya, Supreeta Patil, Aswari Bhosale, B. Dongre, A. Dcruz, A. K. Prabhash, K. ISRN Oncol Clinical Study This study studied the coorelation between radiological response to induction chemotherapy and acheivement of pCR or near pCR. It was a retrospective analysis in which all patients who received NACT from 2008 till april 2012 were subjected to inclusion criteria. Coorelation analysis was performed between CR + PR and acheivement of pCR or near pCR. Twenty four patients were identified.The primary site of tumor was oral cavity in 19 patients (79.2%), maxilla in 2 patients (4.2%), laryngopharynx in 2 patients (4.2%) and oropharynx in 1 patient (4.2%). The clinical stage was stage IVA in 16 patients ( 66.7%) and IVB in 8 patients (33.3%). The overall response rates ie a combination of CR and PR was seen in 11patients (45.8%). The pCR was seen in 15 patients (62.5%) and rest had near pCR. There was no linear coorelation between radiological size decrement and tumor response. On coorelation analysis the spearman correlation coefficent was −0.039 (P = 0.857). This suggest that presently used radiological response criterias for response assesment in head and neck cancers severly limit our ability to identify patients who would have pCR or near pCR. Hindawi Publishing Corporation 2013-09-11 /pmc/articles/PMC3786467/ /pubmed/24109521 http://dx.doi.org/10.1155/2013/259154 Text en Copyright © 2013 V. Patil et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Patil, V. Noronha, V. Joshi, A. Muddu Krishna, Vamshi Juvekar, S. Pantvaidya, Gauri Chaturvedi, Pankaj Chaukar, D. Arya, Supreeta Patil, Aswari Bhosale, B. Dongre, A. Dcruz, A. K. Prabhash, K. Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? |
title | Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? |
title_full | Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? |
title_fullStr | Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? |
title_full_unstemmed | Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? |
title_short | Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy? |
title_sort | is there a limitation of recist criteria in prediction of pathological response, in head and neck cancers, to postinduction chemotherapy? |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786467/ https://www.ncbi.nlm.nih.gov/pubmed/24109521 http://dx.doi.org/10.1155/2013/259154 |
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